Nanobiotechnology for Hemoglobin-based Blood Substitutes
نویسندگان
چکیده
منابع مشابه
Nanobiotechnology for hemoglobin-based blood substitutes.
Nanobiotechnology is the assembling of biological molecules into nanodimension complexes. This has been used for the preparation of polyhemoglobin formed by the assembling of hemoglobin molecules into a soluble nanodimension complex. New generations of this approach include the nanobiotechnological assembly of hemoglobin, catalase, and superoxide dismutase into a soluble nanodimension complex. ...
متن کاملBlood substitutes based on nanobiotechnology.
Stimulated by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise. In this article, nanobiotechnological approaches that are now in phase III clinical trials are reviewed, followed by a discussion of how important basic knowledg...
متن کاملHemoglobin-based red blood cell substitutes.
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems relat...
متن کامل[Hemoglobin-based blood substitutes: current status and perspectives].
BACKGROUND AND OBJECTIVES Alternatives to red blood cells transfusion have been studied since the fifties. This study aimed at presenting current status and perspectives of hemoglobin-based blood substitutes. CONTENTS Potential application areas are presented, in addition to clinical studies involving major hemoglobin molecules developed, their advantages and limitations. CONCLUSIONS Severa...
متن کامل5 Nanobiotechnology - based Blood Substitutes and the Cardiovascular Systems in Transfusion Medicine Thomas Ming
Red blood cell membrane contains blood group antigens, and typing and matching are needed before donor blood can be transfused into patients. This results in delays in emergency situations. Donor blood requires storage at 4oC using standard methods and is good for less than 42 d. Red blood cells cannot be sterilized to remove hepatitis viruses, HIV and other potential emerging infective agents....
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ژورنال
عنوان ژورنال: Critical Care Clinics
سال: 2009
ISSN: 0749-0704
DOI: 10.1016/j.ccc.2008.12.006